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- $Unique_ID{BRK03616}
- $Pretitle{}
- $Title{Colitis, Collagenous}
- $Subject{Colitis, Collagenous Colitis, Ulcerative (Idiopathic Proctocolitis)}
- $Volume{}
- $Log{}
-
- Copyright (C) 1989, 1991 National Organization for Rare Disorders, Inc.
-
- 630:
- Colitis, Collagenous
-
- ** IMPORTANT **
- It is possible that the main title of this article (Collagenous Colitis)
- is not the name you expected. Please check the SYNONYM list to find the
- alternate names and disorder subdivisions covered by this article.
-
- Synonyms
-
- Information on the following disorder can be found in the Related
- Disorders section of this report:
-
- Colitis, Ulcerative (Idiopathic Proctocolitis)
-
- General Discussion
-
- ** REMINDER **
- The information contained in the Rare Disease Database is provided for
- educational purposes only. It should not be used for diagnostic or treatment
- purposes. If you wish to obtain more information about this disorder, please
- contact your physician and/or the agencies listed in the "Resources" section
- of this report.
-
- Collagenous Colitis is a chronic digestive disease characterized by
- changes in the lining of the large intestine (colon). The colon is inflamed
- and contains a thickened layer of the protein collagen in its walls.
- Chronic diarrhea and weight loss also occur.
-
- Symptoms
-
- Collagenous Colitis is characterized by watery diarrhea that may be recurrent
- or chronic. The large intestine is usually inflamed. Mild weight loss and
- abdominal pain also occur. In some cases, Collagenous Colitis may
- spontaneously go into remission whereas in other cases it may be chronic.
- Excessive amounts of a protein (collagen) thickens the wall of the colon
- causing symptoms of the disease.
-
- Causes
-
- The exact cause of Collagenous Colitis is not known. The disorder may be
- caused by injury to the colon wall or by an inflammation that triggers excess
- collagen to accumulate, or by a toxic substance.
-
- Affected Population
-
- Collagenous Colitis affects women in greater numbers than men. Patients are
- usually middle-aged when symptoms begin.
-
- Related Disorders
-
- Symptoms of the following disorder can be similar to those of Collagenous
- Colitis. Comparisons may be useful for a differential diagnosis:
-
- Ulcerative Colitis (Idiopathic Proctocolitis) is an acute non-specific
- inflammatory bowel disorder, characterized by multiple, irregular,
- superficial ulcerations. Thickening of the wall of the colon with scar
- tissue and polyp-like structures occurs, resulting from prolonged
- inflammation. This disorder may involve only the left side of the colon or
- may eventually extend to involve the entire bowel simultaneously. Ulcerative
- Colitis is usually chronic, with repeated periods of exacerbation and
- remission. The chief symptom is bloody diarrhea. (For more information,
- choose "Colitis, Ulcerative Colitis" as your search terms in the Rare Disease
- Database.)
-
- Therapies: Standard
-
- Treatment for Collagenous Colitis with the antibacterial sulfonamide drug
- sulfasalazine may be helpful for reducing inflammation.
-
- Therapies: Investigational
-
- The FDA has approved the following drug for treating as a treatment or
- Collagenous Colitis:
-
- The orphan drug Altracin (bacitracin) is being tested for the treatment
- of antibiotic-associated pseudomembranous enterocolitis caused by toxins A
- and B elaborated by clostridium difficile.
-
- This disease entry is based upon medical information available through
- March 1991. Since NORD's resources are limited, it is not possible to keep
- every entry in the Rare Disease Database completely current and accurate.
- Please check with the agencies listed in the Resources section for the most
- current information about this disorder.
-
- Resources
-
- For more information on Collagenous Colitis, please contact:
-
- National Organization for Rare Disorders (NORD)
- P.O. Box 8923
- New Fairfield, CT 06812-1783
- (203) 746-6518
-
- National Foundation for Ileitis and Colitis
- 444 Park Avenue South
- New York, NY 10016
- (212) 685-3440
-
- National Digestive Diseases Information Clearinghouse
- Box NDDIC
- Bethesda, MD 20892
- (301) 468-6344
-
- References
-
- COLLAGENOUS COLITIS: PHYSIOLOGIC AND HISTOPATHOLOGIC STUDIES IN SEVEN
- PATIENTS: F.M. Giardiello, et al.; Annals Internal Medicine (January 1987:
- issue 106(1)). Pp. 46-49.
-
- COLLAGENOUS COLITIS: H. Rams, et al.; Annals Internal Medicine (January
- 1987: issue 106(1)). Pp. 108-113.
-
- SULFASALAZINE IN TREATMENT OF COLLAGENOUS COLITIS. CASE REPORT AND
- REVIEW OF THE LITERATURE: N. Weidner, et al.; American Journal Medicine
- (July 1984: issue 77(1)). Pp. 162-166.
-
-